Welcome to your go-to
B12 resource!
Browse B12 products and testing options exclusively from Holistic Health
When you order supplements from Holistic Health you can be sure you’re ordering the highest quality.
– All ingredients specifically selected and implemented by Dr. Amy
for her program: The Yasko Protocol.
– All of our custom supplements are made from manufacturers in the USA and stored in a temperature and humidity controlled area.
– Supplements are manufactured in facilities that follow cGMP guidelines.
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Shop B12 supports today!
Methyl B12 MegaDrops™
• Our B12 drops are known to be a premium alternative dietary support that mimic natural sources of energy to kickstart better living
• Each Mega Drop contains 1000mcg for a total of 345,000mcg per bottle
• GREAT option for those who do not like to swallow capsules or have digestive issues
• Learn more about this product
Adenosyl B12 MegaDrops™
• Our new & improved Adenosyl Vitamin B12 liquid supplement is a powerhouse of energy, created to deliver maximum health benefits
• Each serving contains 2,000 mcg for a total of 690,000 mcg per bottle
• GREAT option for those who do not like to swallow capsules or have digestive issues
• Learn more about this product
Hydroxy B12 MegaDrops™
• These B12 liquid vitamin drops are holistic health boosters that promote B12 balance in the body
• Each serving contains 1000 mcg for a total of 345,000 mcg per bottle
• GREAT option for those who do not like to swallow capsules or have digestive issues
• Learn more about this product
Get B12™ Spray
• This unrivaled liquid B12 supplement offers a much needed energy boost without compromising on your need for relaxation
• Our blend of B12 supports the body’s natural ENERGY levels
• GREAT option for those who do not like to swallow capsules or have digestive issues
• Learn more about this product
Black Bear Energy™ Spray
• The combination of two most active Vitamin B12 forms make Black Bear a superior energy supplement; this liquid B12 formula is especially great for nerve health
• Black Bear Energy™ Spray contains a blend of hydroxyl B12 & adenosyl B12
• A single serving of this spray has more than 400 times the amount of B12 than any energy drink on the market
• Learn more about this product
Understand if your B12
supplementation is working
Consider the following at home tests from Holistic Health.
Your test results can be personally reviewed and
commented on by Dr. Amy Yasko.
There is no additional charge for this service. As always, consult with your health care professional.
Running our DNA Test can also give you additional information beyond MTHFR.
hair elements
test
Urine Toxic &
Essential
Elements test
Why do you need B12?
Vitamin B12 is a water-soluble vitamin. This means that it doesn’t stay in the body for a long period of time. Accordingly, more frequent support with B12 may be needed to maintain healthy B12 levels in the body.1
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Vitamin B12 is important for energy production, balance–related sports, endurance, healthy red blood cells, and memory, among other functions in the body.2,3
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Vitamin B12 can be depleted due to poor dietary habits, drinking alcoholic beverages, taking certain medications, and the aging process.2
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Inadequate B12 intake has been associated with fatigue, unhealthy red blood cells, alcohol-induced liver cell damage, abnormal cell growth, cognitive impairments, neural tube defects, memory loss, and feelings of hopelessness.2-4
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Regular B12 supplementation is linked to improved balance, energy, and endurance in athletic individuals.3
Sources
1. Kennedy DO. B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review. Nutrients. 2016; 8(2):68.
2. O’Leary F, Samman S. Vitamin B12 in health and disease. Nutrients. 2010 Mar;2(3):299-316.
3. Mayer G, Kroger M, Meier-Ewert K. Effects of vitamin B12 on performance and circadian rhythm in normal subjects. Neuropsychopharmacology 1996;15:456-64.
4. Smith AD, Refsum H. Homocysteine, B Vitamins, and Cognitive Impairment. Annu Rev Nutr. 2016;36:211-39.
Different types of B12 work best for different people
Vitamin B12 (also called Cobalamin) can include Hydroxy B12, Methyl B12, Cyano B12, and Adenosyl B12.1 Many vitamins (including B12) that are normally found in food are not in an active form. Instead, the body needs to convert inactive B12 into an active form that can be used directly. B12 is needed for the proper functioning of a number of different enzymes.2 However, not all types of B12 are equal. Furthermore, the body cannot easily convert all types of B12 into the forms that are needed for key reactions in the body. Hydroxy, Methyl, and Adenosyl are natural forms of B12 that are also commercially available and can be used directly for numerous reactions in the body.1 Cyano B12 is a synthetic form that must be converted for use in the body. As the name suggests, Cyanocobalamin contains a cyanide molecule.1
Methyl B12
can be readily used in the body, although it is not tolerated by everyone. Those who become jittery after consuming caffeine may not react as well to Methyl B12. Furthermore, many adults do not respond positively to Methyl B12 in spite of their nutrigenomics,3and in such cases, an alternative form is recommended.
HYDROXY B12
(or Hydroxycobalamin) is a unique form of vitamin B12 that is more easily converted to the active form that promotes numerous reactions in the body.1,4 This might cause you wonder why all products would not simply contain high servings of Hydroxy B12 in their formulations. Hydroxy B12 is more difficult to process for manufacturing purposes, it’s harder to store in an active form, and it’s more expensive than some other forms of B12 such as Cyano B12. For these reasons, many other products do not contain Hydroxy B12 and instead use Cyano B12.
ADENOSYl B12
is a special form of B12 that supports energy production in cells throughout the body. It is important to consume Adenosyl B12, however, please know that this form of B12 is not as versatile as the other forms.3,4 This means it can be taken in lower doses.
CYANO B12
contains a cyanide molecule.1 Accordingly, when you take Cyano B12, your body must first turn it into active B12 in order to use it. Your body must then find a way to get rid of the toxic cyanide molecule. It is important to note that cyanide is a poison. This means that even if the rest of the B12 molecule is good for you and the body uses active B12 to excrete cyanide, this form is not particularly safe.5,6 Therefore, Cyano B12 is not the form your body ultimately needs and taking higher servings may deplete your body’s natural levels of active B12.1,6 This may cause you to wonder why anyone would use Cyano B12 if it can be toxic. In low doses, Cyano B12 helps raise the body’s levels of active B12, but for the most part Cyano B12 is used because it is much less expensive.1 It also demonstrates more heat stability than the other forms of B12, which gives it a longer shelf life.1
Sources
1. Paul C, Brady DM. Comparative Bioavailability and Utilization of Particular Forms of B12 Supplements With Potential to Mitigate B12-related Genetic Polymorphisms. Integr Med (Encinitas). 2017;16(1):42-49.
2. O’Leary F, Samman S. Vitamin B12 in health and disease. Nutrients. 2010;2(3):299-316.
3. Gräsbeck R. Hooked to vitamin B12 since 1955: a historical perspective. Biochimie. 2013; 95(5):970-5.
4. Obeid R, Fedosov SN, Nexo E. Cobalamin coenzyme forms are not likely to be superior to cyano- and hydroxyl-cobalamin in prevention or treatment of cobalamin deficiency. Mol Nutr Food Res. 2015; 59(7):1364-72.
5. Carmel R. Efficacy and safety of fortification and supplementation with vitamin B12: biochemical and physiological effects. Food Nutr Bull. 2008 Jun; 29(2 Suppl):S177-87.
6. Foulds WS, Freeman AG, Phillips CI, Wilson J. Cyanocobalamin: a case for withdrawal. Lancet. 1970; 1(7636):35.
Genetic Testing for B12 Support
Genetic Testing can help you determine the best form of B12 to support you. If you have completed Genetic Testing, please consider this DNA Panel. If you are not interested in completing a Genetic Test, Hydroxy B12 and Adenosyl B12 are well tolerated by most1,2:
| COMT V158M | VDR Taq | B12 Types that Should be Tolerated |
| – – | + + (TT) | All 3 types of B12 |
| – – | + – (Tt) | All 3 types with less Methyl B12 |
| – – | – – (tt) | Hydroxy B12 and Adenosyl B12 |
| + – | + + | All 3 types with less Methyl B12 |
| + – | + – | Hydroxy B12 and Adenosyl B12 |
| + – | – – | Hydroxy B12 and Adenosyl B12 |
| + + | + + | Hydroxy B12 and Adenosyl B12 |
| + + | + – | Hydroxy B12 and Adenosyl B12 |
| + + | – – | Mostly Hydroxy B12 |
As always, consult with your health care professional.
Sources
1. Paul C, Brady DM. Comparative Bioavailability and Utilization of Particular Forms of B12 Supplements With Potential to Mitigate B12-related Genetic Polymorphisms. Integr Med (Encinitas). 2017;16(1):42-49.
2. Obeid R, Fedosov SN, Nexo E. Cobalamin coenzyme forms are not likely to be superior to cyano- and hydroxyl-cobalamin in prevention or treatment of cobalamin deficiency. Mol Nutr Food Res. 2015; 59(7):1364-72.
Why is it important to take advantage of B12 supplementation?
“Oral administration of high-dose vitamin B12 (1 to 2 mg daily) is as effective as intramuscular administration for correcting anemia and neurologic symptoms…Absorption rates improve with supplementation; therefore, patients older than 50 years and vegans or strict vegetarians should consume foods fortified with vitamin B12 or take vitamin B12 supplements,”
https://pubmed.ncbi.nlm.nih.gov/28925645
“Vitamin B12 is essential for DNA synthesis and for cellular energy production…Vitamin B12 deficiency is common, mainly due to limited dietary intake of animal foods or malabsorption of the vitamin. Vegetarians are at risk of vitamin B12 deficiency as are other groups with low intakes of animal foods or those with restrictive dietary patterns. Malabsorption of vitamin B12 is most commonly seen in the elderly…”
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257642
“Vitamin B12 is a particularly important vitamin for women of childbearing age and for older people, however, adequate vitamin B12 status over the whole of the lifecycle is needed for optimal health. There has been renewed interest in vitamin B12 since the reporting of associations between homocysteine and chronic disease…”
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257642
About Dr. Amy Yasko
Dr. Amy has a PhD in Microbiology/Immunology/Infectious Disease from Albany Medical College, along with multiple postdoctoral fellowships including Yale Medical center, Wilmont cancer center URMC, and Pediatric Infectious Disease at URMC.
She has served as a member of the scientific advisory board for NFAM (National Foundation of Alternative Medicine) and the Documenting Hope Project for chronic illness. Dr. Amy worked in biotechnology for 15 years, codeveloping the first low cost DNA synthesizer and co owned a DNA technology company as an inventor on multiple patents involving DNA and RNA technology.
Dr. Amy then shifted her focus to using more natural approaches to address complex molecular health issues by additional training and degrees in natural health including a Doctor of Natural Health, a board certified Alternative Medical Practitioner, a board certified Holistic Health Practitioner, and is a Fellow of the American Association of Integrative Medicine.
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I want you to know that this program is unlike any other health program you will encounter. In addition, this is likely going to be a very different experience than you have ever had. This is not a one size fits all program; it truly is a customized program to give you the tools and information that fit your needs and create a personalized map for better health and wellness. Please click here for an informative list of resources that we have made available to support you in your personal health journey.